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Generic Name: Xenical
Brand name: Orlistat
   
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Uses
Xenical is used with a reduced-calorie diet to help significantly overweight persons lose weight. It also helps to prevent regaining weight previously lost. Orlistat works by blocking some of the fat normally digested by the intestine.
How To Use
Take Xenical by mouth, generally three times daily during (or up to one hour after) each main meal that contains fat. Your daily intake of fat, protein and carbohydrate should be evenly spread over three main meals. If a meal is occasionally missed or contains no fat, skip that dose of the medication. Because Xenical can interfere with absorption of fat-soluble vitamins (e.g., A,D,E,K), a daily multivitamin supplement containing these nutrients is recommended. Take the multivitamin at least 2 hours before or 2 hours after Xenical (e.g., at bedtime). The effects of Xenical may begin as soon as 1-2 days after treatment begins; noticeable weight loss will take longer.
Side Effects
• Stop taking Xenical and seek emergency medical attention if you experience a rare allergic reaction including shortness of breath; closing of your throat; swelling of your lips, tongue, or face; or hives.
• Other, less serious side effects are more likely to occur. Continue to take Xenical and talk to your doctor if you experience
· oily spotting,
· gas with discharge,
· an urgent need to go to the bathroom,
· oily or fatty stools,
· an oily discharge,
· an increased number of bowel movements,
· an inability to control bowel movements, or
· orange or brown colored oil in your stool.
• The bowel changes listed above are a natural effect of blocking fat and indicate that Xenical is working. They generally occur early in treatment, particularly after meals containing higher amounts of fat than are recommended. These symptoms are usually temporary and lessen or disappear as you continue treatment and keep to your recommended diet of meals containing 30% fat.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Precautions
Tell your doctor your medical history, including: allergies, digestive disorders (malabsorption or cholestasis), low thyroid function (hypothyroidism), other metabolism problems (e.g., oxalate kidney stones, hyperoxaluria). Xenical< should not be used if you have anorexia nervosa or bulimia-type eating disorders. Tell your doctor if you are pregnant before using Xenical. The manufacturer does not recommend use of Xenical during pregnancy. It is not known whether Xenical is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using Xenical is not recommended. Consult your doctor before breast-feeding.
Drug Interactions
Tell your doctor of all prescription and nonprescription medication you use, especially of: cyclosporine, "blood thinners" (e.g., warfarin), drugs for diabetes (e.g., insulin), other drugs used for weight loss. Cyclosporine should be taken at least 2 hours before or after orlistat to assure maximum absorption of the cyclosporine into your bloodstream. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose of Xenical is suspected, contact your local poison control center or emergency room immediately.
Notes
Do not share Xenical with others. Follow your doctor-approved nutritional, reduced-calorie diet containing about 30 percent calories from fat. Also, exercise is recommended; however, first consult your doctor or pharmacist.
Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Store at room temperature (77 degrees F, 25 degrees C) away from light and moisture.
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