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Generic Name: Celebrex
Brand name: Celecoxib
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Uses
Celebrex is a nonsteroidal anti-inflammatory drug (NSAID) which relieves pain and inflammation (swelling). It is used to treat pain, swelling and stiffness due to arthritis. Celebrex works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.
How To Use
Take by mouth, generally once or twice daily, as directed by your doctor. To decrease the chance of stomach upset, Celebrex is best taken with food. Dosage is based on your medical condition and response to therapy. Take Celebrex with 6 to 8 ounces (180-240ml) of water. Do not lie down for at least 30 minutes after taking Celebrex.
Side Effects
Serious but rare side effects that have been reported in patients taking Celebrex are delineated below :
- Serious stomach problems, such as stomach and intestinal bleeding, can occur with or without warning symptoms. These problems, if severe, could lead to hospitalization or death. Although this happens rarely, you should watch for signs that you may have this serious side effect.
- Serious allergic reactions including swelling of the face, lips, tongue, and/or throat which may cause difficulty breathing or swallowing and wheezing occur rarely but may require treatment right away. Severe skin reactions have also been reported.
- Serious kidney problems occur rarely, including acute kidney failure and worsening of chronic kidney failure. - Severe liver problems, including hepatitis, jaundice and liver failure, occur rarely in patients taking NSAIDs, including Celebrex. Symptoms of liver problems include nausea, tiredness, itching, tenderness in the right upper abdomen, and flu-like symptoms.
In addition, the following side effects have been reported: anxiety, confusion, depression, hair loss, hallucinations, increased levels of potassium in the blood, low blood cell counts, palpitations, pancreatitis, tingling sensation, unusual headache with stiff neck (aseptic meningitis), vertigo.
Precautions
Tell your doctor your medical history, including: allergies (especially allergies to drugs such as sulfas or NSAID like ibuprofen), kidney problems, liver problems, heart disease, alcohol use, high blood pressure, swelling (edema), blood disorders (anemia), serious infections, stomach problems (bleeding or ulcers), asthma, growths in the nose (nasal polyps), dehydration, poorly controlled diabetes. This medicine may cause stomach bleeding. Daily use of alcohol, especially when combined with this medicine, may increase your risk for stomach bleeding. Check with your doctor or pharmacist for more information. Celebrex should be used only when clearly needed during the first 3 months of pregnancy. It is not recommended for use during the last 6 months of pregnancy. Discuss the risks and benefits with your doctor. It is not known whether Celebrex is excreted into breast milk. Due to the potential risk to the infant, breast-feeding while using Celebrex is not recommended. Consult your doctor before breast-feeding. Caution is advised when Celebrex is used in the elderly, as they may be more sensitive to the side effects of Celebrex.
Drug Interactions
Include on your medical history/personal profile all of the other medicines you are taking or plan to take while you are on Celebrex, even other medicines that you can get without a prescription.
Celebrex has significant drug interactions with :
- Methotrexate (a medicine used to suppress the immune system).
- Warfarin (a blood thinner).
- Rifampin (an antibiotic).
- ACE inhibitors (medicines used for high blood pressure and heart failure).
- Lithium (a medicine used to treat a certain type of depression).
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Notes
Do not share Celebrex with others. Laboratory and/or medical tests may be performed to monitor your progress.
Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Storage
Store at room temperature between 59 and 86 degrees F (15 - 30 degrees C) away from light and moisture.
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